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Drug disposition (Absorption (Single compartment model (First order…
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IV infusion, patch, depot injection
More accurate as generally equilibrium is achieved instantaneously for some tissues but for others not.
Oral, inhaled, transdermal, IM, SC injections
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Describes the relationship between Fu in plasma and tissue with effect on the overall volume of distribution, taking into account the different volume of distributions found in plasma as well as the tissues.
Different kinds of transporters, perfusion, binding of drugs
Lipid soluble drugs are re-absorbed. As the gall bladder emulsifies fats for re-absorption into the body.
Conjugates attached to drugs produced by liver metabolism may be cleaved off by bacteria causing the drug to be re-absorbed
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By product of muscle metabolism, if renal function is impaired then serum creatine levels will rise
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