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HIV (Delta32 CCR5 Mutation (West Nile Virus (delta 32 CCR5 increases…
HIV
Delta32 CCR5 Mutation
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Conversely, CCR5P1 haplotype - independent variants in CCR5 promoter accelerate disease progression as higher expression - Martin/McDermott 1998
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CCR5/CCR2
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CCR5 promoter and upstream CCR2 - strong linkage of delta32 CCR5, promoter and and CCR2 V 64 I
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HHC delayed in causasian, not a american
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Response to therapy
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nucleoside analogue, inhibitor of viral reverse transcription
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all hypersensitive carry , 39% of all with genotype hypersensitive - COMPLEX
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Disease
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Natural Immunity
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viremia during acute infecion, CD4+ T cell depletion, progression to AIDS all vary between individuals
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Epigenetics
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current therapeutics aiming to reactivate all virus then kill for curative therapy but currently Vorinostat latency reversing agent has been unsuccessful
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RANTES
Regulated upon Activation, Normally T cell Expressed, Presumably Secreted
C-C chemokine, natural ligand for CCR5
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decreases affinity for nuclear binding proteins, 4x lower expression, more CCR5 available for HIV-1 binding
Case-control analysis
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GWAS
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HIV MHC
HLA-B*35-PY slower progression to AIDS - increased CD8+ T cell response to HIV peptide fragements like Gap p24
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