Please enable JavaScript.

Coggle requires JavaScript to display documents.

Fertility Treatment (EMBRYOLOGY (PGB = Preimplantation Genetic Diagnosis…

- - - - HFEA Regulations
        
        18-45
        
        Free from intectious/hereditary disease
        
        Understand implications of identifying information being released to offspring
        
        12 month total commitment (with 6 month donations + 6 month quarantine period)
        
        Internationally recognised ID
        
        Max 10 families
- - - - HFEA Regulations
        
        18-35
        
        Free from Infectious/Hereditary Disease
        
        Understand identification implications
        
        Restricted to max 10 families
        
        Only 1-2 egg collections
- - - - Semen Analysis
      - AMH Profile
      - Mandatory Infectious Disease Screen
      - Optional Day 8-12 Hycosy = Hysterosalpingo contrast sonography
  - - - Common Pills
        
        CLOMIPHENE
        
        LETROZOLE
        
        TAMOXIFEN
      - OR Timed FSH/LH/GnRH Agonist Infections
      - Collection of egg via aspiration under ultrasound guidance
      - Response is individual-specific, sometimes OVARIAN HYPERSTIMULATION SYNDROME is induced
  - - - PESA = Percutaneous Epididymal Sperm Aspiration
      - MESA = Microsurgical Epididymal Sperm Aspiration
      - TESE = Testicular Sperm Extraction
- - - - Genetic Counselling + Confirmatory Testing - ensure necessary / appropriate tests are being provided
      - Embryos must remain in culture longer than routine IVF to allow for sufficient development to permit safe removal of cells from each embryo
      - Rapid FISH / PCR - Based Laboratory Tests to allow embryo selection + transfer the morning after biopsy
        
        Single Cell Tests = Chromosome Disorders + Sexing
        
        PCR = Single Gene Disorders
        
        e.g. 145 peak instead of 148 = CF positive
        
        FISH = Chromosome Disorders
        
        Chromosome disorders = leading cause for pregnancy loss
        
        However can only detect 5 chromosomes at a time
      - Follow-up of pregnancies + children born as technique is still in its infancy
      - Unaffected embryos transferred to womb
    - - Potential Solution is MICROARRAYS to detect any chromosome disorder