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Clostridia (General Characteristics (perfringens (gut-flora, but minor,…

- - - - food-borne (adults)
      - wound = bacteria in
      - infant = child ingests spore (raw honey): floppy baby
      - adult intestinal toxemia
      - introgenic = paralysis from botulinum toxin injection
- - - - beef
      - poultry
      - gravy
      - dried/pre-cooked foods
      - foods kept warm but not hot
- - - - gangreen, hemolysis, cellulitis
  - - - neuromuscular junction
      - peripheral nerve
      - Acetylcholine release prevention
      - flaccid paralysis
  - - - pseudomembranous colitis
      - toxic megacolon
      - colon perforations
      - sepsis
      - death
    - - antibiotic exposure
      - proton pump inhibitors
      - gastrointestinal surgery
      - immunocompromization
      - age
- - - - mechanical ventilation