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Shigella (General Characteristics (shigellosis, bacterial dysentery, human…
Shigella
General Characteristics
shigellosis
bacterial dysentery
human intestinal disease
most common in young children
gram -
straight rods
non-motile
enteric
intracellular - does not penetrate beyond endothelium
Symptoms
diarrhea with blood
mucus in stool
painful abdominal cramping
young
old
malnourishment
severe dehydration --> death
resolves in a week typically
Transmission
oral/fecal route
humans preferred host
transient flora in lesser mammals
low infectious dose
10-100 viable organisms to infect
crowding
poor sanitation
Toxin
A = binds cell
B = blocks ribosome
inhibit protein synthesis of cell
Treatment = not-recommended