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genomics (bioinformatic analysis (INSDC (international nucleotide Sequence…

- - - - reference genome
- - - - protein coding region
        
        splicing (exon/intron) > mRNA
        
        translation
        
        peptide (aa seq) >protein
        
        transportation of protein?
        
        DNA extraction (isolates)
        
        DNA fragmentation
        
        polypeptide > polyprotein
        
        functional protein
      - non-coding region/gene
        
        regulation of gene expression (rRNA, ribosome?)
        
        methylation/enhancer/silencer
        
        translation initiation (ribosome), protein structural stability
        
        mRNA stability (poly-A tail), transportation of mRNA
- - - - needleman-wunsch
      - smith-waterman
- - - - contamination removal
        
        quality filtering
        
        k-mer counting (kraken)
        
        genome size estimation
        
        error rate estimation (>50x coverage)
        
        read error correction
        
        de-novo assembly
        
        1 more item...
        
        read mapping (SAMtools)
        
        1 more item...
        
        Taxonomy classification
- - - - Next generation (illumina) sequencing (high -throughput)
        
        sequence quality {FastQC}
        
        Phred quality score (fastq)
- - - - Large region of variance
        
        SNV/substitution
        
        If common
        
        SNP
        
        allele
        
        homolog
        
        2 more items...
        
        heredity
        
        2 more items...
        
        heterogyous/homozygous
        
        synonymous/silence
        
        non-synonymous
        
        missence
        
        truncated protein
        
        lethal
        
        Indel
        
        frame shift
      - Large region of variance
        
        copy number variant (CNV)
        
        Structural Variance (SV)