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GI Cancers (Colorectal (1st hit (Mutation APC) (At risk- methylation, B…
GI Cancers
Colorectal
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1st hit (Mutation APC)
At risk- methylation, B-catenin
Adenoma: KRAS, LoH, COX-2^
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Neoplasia: Colonic adenomas, FAP
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20% emergency: Colicky, abdo distention, vom.
Narrow: Sigmoid colon, ileocecal valve
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Duke's staging: muscularis extend, lymph, met (Usually to Liver).
Oesophageal
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70+, odyno/dysphagia, Wtloss, 20% survival.
Pancreatic
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60-80s, KRAS oncogene^, CDKN2A Tumour Supp.
Gastric
Intestinal
Precursor adenoma. APC, ^B-catenin
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50-60s, early chronic gastritis -> wtloss
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Neoplastic Polyps
usually silent, 60+ surveillence in 50+ w/ FH