Further into the book, Harding explains how the Big Nurse has manipulative tactics on having the patients think about their actions. For example, if a patient used a kleenex, and Big Nurse found it, she would come up to the patient and ask what they used that kleenex for. If the patient said "a pen" or that they had "a cold", Big Nurse would simply say "Oh, I see."
Harding explains that Big Nurse does this to insinuate that the patient might've done something else with the kleenex, for example, which leaves the patient wondering what exactly they did do.
This can cause conflict
Harding also talks about the circle of life, about how "the wolf preys on the rabbit, and the rabbit knows his place. It wouldn't be smart for the rabbit to challenge the wolf. It wouldn't make sense." He explains how everyone are rabbits, and how the Big Nurse is the wolf. That she teaches them their places.
McMurphy is displeased, and doesn't want to be classified as a rabbit. This can cause further conflict between the Big Nurse and McMurphy.