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DNA replication (Prokaryotic (2 birectional replication forks, Helicase…
DNA replication
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Semi conservative replication, Meselson and Stahl
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Enzymology
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DNA polymerase
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a, g, d, and e in eukaryotic
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Telomeres
DNA replication results in the shortening of lagging strand because DNA polymerase does not replace the primer of the last ozaki fragment = terminal gap
Multiple repeats of non coding DNA extends the leading strand so it acts as a template for lagging strand to restore length and no coding DNA is lost
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Only in germ cells, somatic cells carry out apoptosis when their telomeres get too short
Treating disease
Azidothymidine + 2' 3' dideoxycytidine is a nucleoside analogue that lacks a 3'OH group so inhibits replication
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