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Dermatology (Alopecia (Canine Demodicosis (Generalized (Tx (Amitraz (핥아먹지…
Dermatology
Alopecia
Alopecic breeds : Mexican Hairless dog, Chinese Crested dog, Inca Hairless dog, American Hairless terrier, Sphinx cat
Primary : 내분비 질환(갑기저, HAC), follicular dysplasia, telogen effluvium, anagen defluxion
Secondary : pruritus, bacterial folliculitis, dermatophytosis, demodicosis
Canine Demodicosis
not contagious, part of normal flora ← 유전적인 영향 많음.
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C/S : alopecia, severe crusting & ulceration, oily & greasy skin, lymphadenopathy, fever, anorexia, secondary bacterial folliculitis or even cellulitis
Localized
one to several small, circumscribed, erythematous, scaly nonpruritic to pruritic areas of alopecia
usually on face, around eyes or on forelegs
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Generalized
also seen in adults(>4yrs) indicates an underlying immunosuppressive disorder(HAC, hypothyroidism, neoplasia, exogenous corticosteroids)
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C/S : prominent follicular casts, seborrheic changes(alopecia+scaling+crusting), secondary pyoderma(common; can be pruritic)
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Tx
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4주마다 재검사, 적어도 5 skin scrapings
Amitraz
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Can be sedative for 12~24hr(intoxication : yohimbin, atipamezole)
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Species
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Large bodied Demodex injai : greasy skin, dorsal distribution(scraping 시 찾기 쉽지 않음.)
Feline Demodicosis
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Demodex gatoi : contagious and causes pruritic skin dz; a stratum corneum mite, not a follicular mite
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Generalized form
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generalized demodicosis w/ D.cati usually associated w/ underlying dz : DM, FeLV, FIV, SLE, HAC, SCC
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Tx : lime sulfur, ivermectin, amitraz(당뇨가 있는 고양이에게는 사용x)
Dermatophytosis(Ringworm, Tinea)
Microsporum, Trichophyton
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single, multifocal circular patches of alopecia w/ variable scaling
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Dermatophyte kerion : boggy, exudative, variably well-circumscribed, nodular type of furunculosis that may develop multiple draining tract
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Superficial pyoderma : impetigo, mucocutaneous pyoderma, superficial bacterial folliculitis
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Color-dilution alopecia : Dobermann Pinchers, Yorkies, etc.
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Keratinization Disorders
Keratinization defects
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Congenital : primary seborrhea, ichthyosis, etc.
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Keratinization
Intrinsic factors : IGF, PDGF, TGF, TNF, IFN, etc.
Hormone : Epi, Vit D, cortisol, thyroid
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Nutrition : protein, fatty acids, Zn, Cu, Vit A & B ← usually malabsorption, maldigestion, metabolic dz
Inflammation : dermal eicosanoids, histamine, cytokines, LTB4 eg. early epitheliotropic lymphoma
Environmental factors : low humidity, excessive bathing
Clinical features : flakiness, greasiness, seborrheic dermatitis, ceruminous otitis externa
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Tx
Keratinolytic : benzoyl peroxide, propylene glycol, 20% urea
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Keratinolytic+Keratoplastic : sulphur, salicylic acid, tar, selenium sulphide
Barrier restoration : linoleic acid, free fatty acids, lanolin, mineral oil, vegetable oils, Vit E
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Disorders
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Primary seborrhea : American cocker spaniel, English springer spaniel, Dachshund, Dobermann pinscher
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Vit A-responsive dermatitis : Cocker spaniel에서 잘 발생. 치료는 10000U Vit A(retinol) PO SID w/ a fatty meal
Zinc-responsive dermatosis : young adult Northern breeds(Siberian huskies, Samoyeds, Alaskan malamutes)
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