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Exploring the molecular machinery of Hypoxia sensing and response pathway…

- - - - Normoxia
        
        HIF-1a degradation in oxygen dependent manner by PHD2
      - Hypoxia
        
        HIF-1a become stabilised in hypoxic condition
        
        Translocate to the nucleus and activate hypoxia responsive gene
        
        KDM increase the HIF heterodimer binding efficiency by chromatin remodelling
        
        Suppress certain oxygen consuming processes
        
        Oxidative phosphorylation
        
        Protein synthesis
        
        Ribosome biogeneis
        
        Activate negative feedback mechanism to restore the function
        
        HIF mediated transcriptional activation of PHD2
        
        Redistribution of molecular oxygen for the activation of PHD2
- - - - Energy metabolism
        
        SLC2A1
        
        HK2
        
        ALDOC
        
        PFKFB3
      - Cell migration
        
        CXCR4
      - Autophagy
        
        BNIP3
        
        Beclin1
        
        LC3
      - Vasomotor regulation
        
        Endothelin1
        
        a 1b-adrenogenic receptors
      - Hormonal regulation
        
        Erythopoietin
        
        Leptin
      - Angiogenic regulation
        
        VEGFA
- - - - Differences at the biological pathways
      - Differences at their biochemical parameters
      - Differences at biological processes
      - Provide a molecular link to study hypoxia responsiveness
        
        Help us to identify inter-individual differences toward hypoxia
- - - - which provide us a window to study and understand inter-individual variability with respect to hypoxia
  - - - LCLs
        
        Cost effective and widely used as a tool to study gene expression
        
        Constant source of DNA, RNA, and Protein
        
        It can further reprogrammed to iPSCs
        
        Reprogrammed into specific cell lineage
        
        Tool to develop disease specific cellular model