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Diphtheria (Symptoms (Complications (death (1/10 die w/ treatment, 1/2 die…
Diphtheria
Symptoms
sore throat
weakness
fever
swollen glands
pseudomembrane formation
bleeding
toxin
Complications
airway blockage
myocarditis
polyneuropathy
paralysis
pneumonia
death
1/10 die w/ treatment
1/2 die w/o treatment
General Characteristics
Corynebacterium diphtheriae
gram positive
rod
Hanzi character resemblance
bacteriophage mediated
viral gene encodes toxin
not all strains produce toxin
Transmission
respiratory secretions
skin lesions
open sores
contaminated objects
Treatment
vaccine
DTaP
Tdap
DT
Td
antitoxin
antibiotic
48 hour isolation
Toxin
A = inhibits protein synthesis + inhibits eEF-2
B = binding component + epidermal growth factor precursor
1 molecule kills 1 cell