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Oxytocin (Pharmacokinetics (Elimination (Placenta, Ovaries, Spleen, Liver)…
Oxytocin
Pharmacokinetics
Half Life
3 - 15 minutes
First Pass Effect?
Metabolism
Elimination
Placenta
Ovaries
Spleen
Liver
Distribution
Absorption
Lipid/water soluble?
Peak plasma time
Side Effects
Uterine overstimulation
Contraction of umbilical blood vessels
Antidiuretic effect
Changes in blood pressure
Brady/tachycardia
Uses of drug
Aid in management of retained placenta
Into umbilical vein
Management of PPH
30iu in 500mL N/S at 167mL/hour until bag is empty
Prevention of PPH in third stage of labour
5iu IVI for history of cardiac conditions
10iu IMI for any risk factors historically/antenatally or during labour as per policy
Induction/augmentation of Labour
IVI - 30iu in 500mL N/S titrated to individual needs as per
Queensland Clinical Guidelines
Acts within 1-4 minutes and lasts for 20 minutes after disconnection
Routes of Administration
IVI 10iu via slow (3-5 minute) push. Can be given twice up to a maximum of 20iu
IMI 10iu via IMI up to a maximum of 2 doses (20iu)
Indications
Prevention of post-partum haemorrhage for high risk women
Induction or augmentation of labour
Categories
Pregnancy
A* - No proven increase in malformation or harmful fetal effects
Lactation
L2 - Limited data-probably compatible
Agonist
Does not supress the endogenous oxytocin from being produced
Oxytocin in the third stage of labour
May have to remove this