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GI Immunology (IgA (Monomer in blood, dimeric in mucosa, Transcytosis of…
GI Immunology
IgA
Monomer in blood, dimeric in mucosa
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Roles: Limits access to mucosa,
Prevents adherence, neutralisation, maintain symbiosis
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Clinical
5-ASAs: Sulphaslazine, mesalazine- Reduce immune response.
Corticosteriods- prednisolone, hydrocortisone.
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Immune suppressants- Azathioprine, Methotrexate
Brio- Infliximab, adalimumab- Anti- TNF-α Moabs
Intestinal epithelium
Tight jct, Goblet cells-> mucins
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CD4+ Th Cells
Effector
Th1 (intracellular) , Th2 (extracellular-helminths). , 17.
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Regulatory
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Organised: Peyer's Patches- SI, ILF - Small and Large Int
MLN- Largest in body, links lymph of lamina propria
M cells: Layer covering P'Ps. Take up and transport antigen to basal layer, to DC
IBD
Crohn's
Chronic Inflammation, granulomas, crypts and fistulae
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Ulcerative Colitis
Distal colon and rectum, less ileum
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Pyrexia, pseudopolyps, Poo (bloody), proctitis, lead pipe radiology
DC Conditioning
IL-10, TGF-β, PPAR-γALDH1A2 (Conditioned), TGF-B^, IL-12 inhibited