Please enable JavaScript.
Coggle requires JavaScript to display documents.
Progestins (Indications (CHILDREN:Have undergone little testing in…
Progestins
Indications
CHILDREN:Have undergone little testing in children. They can cause premature closure of epiphysis so caution is important in growing children.
ADULTS:Women taking estrogen should be advised not to smoke because of the increased risk of thrombotic events.
Drugs are used in treatment of specific cancers in males and they should be advised about the possibility of estrogenic effects.
Not indicated during pregnancy or lactation because of potential for adverse effects on the fetus or neonate.
-
Nursing consideraction
contraindications
Pelvic inflammatory disease (PID), sexually transmitted diseases, endometriosis, pelvic surgery
-
Drosperinone is contraindicated in patients who are at risk for hyperkalemia due to its antimineralocorticoid effects and the risk of hyperkalemia.
Epilepsy, migraine headaches, asthma, cardiac or renal dysfunction. Potential exacerbation of these conditions.
Adverse effects
-
Dermal patch contraceptives are associated with same systemic effects, as well as local skin irritation.
Vaginal gel use is associated with headache, nervousness, constipation, breast enlargement, and perineal pain.
Intrauterine systems are associated with abdominal pain, endometriosis, abortion PID, and expulsion of the intrauterine device.
-
Route of adminstraction
progestin, norethindrone acetate has been widely administered to patients in the form of oral contraceptive
however, its hypolipemic action has received little study.
-
Therapeutic action
Transform the proliferative endometrium into a secretory endometrium. They also inhibit the secretion of FSH and LH.
-
Exact mechanism of action in its function as a contraceptive is not known but it it thought that circulating progestins and estrogens “trick” the hypothalamus
pituitary and prevent the release of gonadotropin-releasing hormone (GnRH), FSH, and LH.
Mechanism of action
Progesterone binds and activates its nuclear receptor, PR,
which plays an important part in the signaling of stimuli that maintain the endometrium during its preparation for pregnancy.
Progesterone binds and activates its nuclear receptor, PR, which plays an important part in the signaling of stimuli that maintain the endometrium during its preparation for pregnancy.
interactions
Barbiturates, carbamazepine, phenytoin, griseofulvin, penicillin, tetracyclines, rifampin: reduced effectiveness of progestins
St. John’s wort: can affect the metabolism of progestins and can make progestin-containing contraceptives less effective
-