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metabolism osteoporosis drugs (alendronate (mechanism action (Alendronate…
metabolism osteoporosis drugs
alendronate
mechanism action
Alendronate inhibits osteoclast activity and bone resorption. By binding to calcium salts, alendronate blocks the transformation of calcium phosphate into hydroxyapatite and inhibits the formation, aggregation, and dissolution of hydroxyapatite crystals in bone
indication
Prevention in postmenopausal women, Treatment in postmenopausal women and men, Glucocorticoid-Induced Osteoporosis
root of administration
Administer oral solution
contraindication
esophageal stricture or achalasia, increased risk of aspiration,
side effect
heartburn, upset stomach, stomach pain, nausea, diarrhea, constipation, bone pain, muscle or joint pain
storage condition
at room temperature away from light and moisture
risedronate
mechanism action
Risedronate is a heterocyclic orally active aminobisphosphonate and it belongs to the bisphosphonate category: these drugs are powerful bone resorption inhibitors
side effect
chest pain, new or worsening heartburn, difficulty or pain when swallowing, pain or burning under the ribs or in the back, severe heartburn, burning pain in your upper stomach, or coughing up blood
indications
Postmenopausal Osteoporosis, Glucocorticoid-Induced Osteoporosis, Paget Disease, Osteogenesis Imperfecta (Orphan)
contraindications
hypocalcemia, hypersensitivity to any of its components, inability to stand or sit upright for at least 30 minutes
storage conditions
Store at controlled room temperature (between 68 and 77 degrees F)
root of administration
ntravenous
zoledronic acid
mechanism ot action
Mechanism of action. Zoledronic acid is a potent inhibitor of bone resorption. ... Zoledronic acid inhibits farnesyl diphosphate (FPP) synthase and in addition the cellular biosynthetic, FPP synthase-mediated mevalonate pathway
indications
Reduction in incidence of fracturesPrevention in postmenopausal women, Treatment in men and postmenopausal women, Glucocorticoid-Induced Osteoporosis, Paget Disease
root of administration
IV injectable solution
side effect
Flu like symptoms, Low levels of calcium in your blood,Feeling or being sick, A drop in the number of red blood cells, Eye problems
contraindication
severe renal impairment,ncreased risk of renal failure, history of angioedema, serious rash, severe hypersensitivity reaction to the drug
storage condition
Store at a temperature of ≤30°C
calcitonin salmon
mechanism action
Miacalcin nasal spray, like natural calcitonin, acts primarily by inhibiting osteoclasts, the cells that break down existing bone, thereby decreasing the rate of bone breakdown, allowing the body to build bone naturally
side effect
runny nose,nosebleed, sinus pain, nose symptoms such as crusts, dryness, redness, or swelling, back pain, joint pain, upset stomach, flushing (feeling of warmth)
root of administration
subcutaneous, intramuscular, and intranasal routes
indications
high levels of calcium in the blood (hypercalcemia),Postmenopausal Osteoporosis
contraindication
If anaphylaxis or other severe hypersensitivity/allergic reactions occur, suspected hypersensitivity to calcitonin-salmon, low amount of calcium in the blood,vitamin D deficiency, malignant tumor or cancer
storage condition
keep the medicine at room temperature, away from light and heat.Store unopened calcitonin nasal in the refrigerator,