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Male Hormonal drugs (Androgens (Indications (used for treatment of…
Male Hormonal drugs
Androgens
Danazol
Mechanism of action
Growth and development of male sex organs and the maintenance of secondary male sex characteristics.
Increase the retention of nitrogen, sodium, potassium, and phosphorus and decrease the urinary excretion of calcium.
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Nursing considerations
Contraindications
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Pregnancy, lactation. Potential adverse effects on the neonate. It is not clear whether androgens enter breast milk.
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Liver dysfunction, CV disease. Can be exacerbated by the effects of the hormones.
Topical forms of testosterone have a Black Box Warning alerting user to the risk of virilization in children who come in contact with the drug from touching the clothes and skin of the man using the drug.
Danazol has Black Box warning regarding the risk of thromboembolic events, fetal abnormalities, hepatitis, and intracranial hypertension.
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Anabolic steroids
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Indications
Anemias, certain cancers, and angioedema
Promote weight gain and tissue repair in debilitated patients and protein anabolism in patients who are receiving long-term corticosteroid therapy.
Also known to be used illegally for the enhancement of athletic performance by promoting increased muscle mass, hematocrit, strength, and endurance.
Nursing considerations
Contraindications
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Pregnancy, lactation. Potential masculinization in neonates.
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Coronary disease. Potentional increase in cholesterol level through the effect of the drug on the liver.
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