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MALE AND FEMALE HORMONAL DRUGS (SIDE EFFECTS (flushing (warmth, redness,…
MALE AND FEMALE HORMONAL DRUGS
SILDENAFIL
ROUTE
oral
MECHANISM OF ACTION
the physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation.
NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate
producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.
sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5
INDICATIONS
treatment of erectile dysfunction
CONTRAINDICATIONS
Hypersensitivity to the drug
if you take any medication called nitrates
cardiovascular disease
SIDE EFFECTS
flushing (warmth, redness, or tingly feeling);
headache, dizziness;
abnormal vision (blurred vision, changes in color vision)
runny or stuffy nose, nosebleeds;
hearing loss
hypotension
STORAGE
store at room temperature
away from light and moisture
do not store in the bathroom
keep medication away from children