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antifungal drugs (FLUCYTOSINE ((CONTRAINDICATONS ((low amount of potassium…
antifungal drugs
FLUCYTOSINE
CONTRAINDICATONS
low amount of potassium in the blood
aplastic anemia due to medication
decreased function of bone marrow
decreased blood platelets
decreased white blood cells
low level of granulocytes in the blood
liver problems
abnormal liver function tests
a mother who is producing milk and breastfeeding
kidney disease with likely reduction in kidney function
SIDE EFFECTS
Chest pain
diarrheoa
bad belly pain
shortness of breath
seizures
swelling of limbs
mood changes
INDICATIONS
cryptococcus
chromycosis
candida
STORAGE
keep drugs in safe place
store in a dry place
store in room temperature
MECAHNISM OF ACTION
Its an intrafungally converted into the cytostatic fluorouracil which undergoes further steps of activation and finally interacts as 5 fluorouridine triphosphate with RNA bio synthesis thus disturbing building of essential protiens.
ROUTE
intravenous
orally
DEFINITION
Its a less toxic drug that alters the cell membrane of susceptible fungi causing cell death.
FLUCONAZOLE
CONTRA INDICATIONS
liver disease;
HIV or AIDS;
cancer;
heart disease or heart rhythm disorder;
long QT syndrome (in you or a family member);
kidney disease;
SIDE EFFECTS
Chills
clay-colored stools
cough
dark urine
diarrhea
difficulty with swallowing
dizziness
fast heartbeat
MECHANISM OF ACTION
fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase. Mammalian demethylase activity is much less sensitive to fluconazole than fungal demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent accumulation of 14α-methyl sterols.
STORAGE
in room temperature
away from sunlight
away from reach of children
ROUTE
intravenous
oral
DEFINITION-Fluconazole is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood
INDICATIONS
fungal infections.
Prevention of fungal infections.
vaginal yeast infections.