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antiarthritic drugs and skeletal muscle relaxants[NSAIDs,anti-inflamatory…
antiarthritic drugs and skeletal muscle relaxants[NSAIDs,anti-inflamatory steroids and DMARDs]
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penicillamine
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indications
penicillamine is used to treat Wilson's disease,cystituria, and patients with severe,active,rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy.
mechanism of action
penicillamine is a chelating agent recormended for the removal of excess copper in patients with wwilsons disease.
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methotraxate
firmly it is esttablished as a second line drug and chemically it is an antagonist of folic acid and is cytotoxic.
mechanisim of action
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it was also found to slow disease progression in rhuematic arthritis in terms of joint and bone damage.
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drug name
chloroquine
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nursing consideration
observe for ototoxins[tinitus,vertigo,changes in hearing ability.]
observe for alergic reactions such as pluritis,rash,urticaria.
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toxicity is a problem,observe for signs
contraindications
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chloroquine is contraindicated to patients with hearing loss,anemea and alcoholism
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side effects
headache,diarrhea,stomach pain,loss of appetite,hairloss,mood and mental changes
storage condition
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upon resuspension, chloroquine should be stored at 4degres
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