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Selective estrogen receptor modulators (SERMs). (side effects (swelling in…
Selective estrogen receptor modulators (SERMs).
Raloxifene
mechanism of action
Raloxifene is an estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM). The biological actions of raloxifene are largely mediated through binding to estrogen receptors. This binding results in activation of estrogenic pathways in some tissues (agonism) and blockade of estrogenic pathways in others (antagonism). The agonistic or antagonistic action of raloxifene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promoters
indications
prevention of osteoporosis in postmenopausalwomen
reduces breast density
reduction of risk and treatment of invasive breast cancer
contraindication
deep vein thrombosis
pulmonary embolism
venous Thromboembolism
retinal vein thrombosis
side effects
swelling in your hands, feet, or ankles
joint pain
leg cramps
flu symptoms
hot flashes
increased sweating
stomach pain
stroke
runny or stuffy nose
storage
away from sunlight
store in a cool dry place
Store at controlled room temperature, 20° to 25°C