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Male and female hormonal drugs (Progesterons (Side effects (Abdominal…
Male and female hormonal drugs
Testosterone
Mechanism of action
Produced by the testes in males but also by the adrenal glands
Control development and maintainence of male secondary sex characteristics
Increase retention of nitrogen, calcium, sodium, potassium, chloride and phosphate
Indications
Hypogonadism
Acute and chronic renal failure
Inoperable breast carcinoma
Long term corticosteroid therapy
Aplastic anaemia
Contraindications
During pregnancy
During breast feeding
Side effects
Acne, rash, skin flushing
Virilisation
Increased frequency or persistence of erections
Priapism
Excessive sexual stimulation, increase in libido
Storage conditions
Keep on cool dry place
Room temperature
Route of administration
Intra mascular
Orally
Transdermal
Progesterons
Mechanism of action
Regulation of mammalian reproduction.
second gene family, the Steroid Receptor Coactivator (SRC) family, has been identified that serves to modulate the transcriptional activity of the hormone receptors.
Indications
Endometriosis
Breast and endometrial cancer
Progesterone insufficiency
Threatened abortion
Adjunct to oestrogen replacement therapy
Contraindications
Thrombophlebitis
Active or previous history of thromboembolism
Myocardial infarction
Side effects
Abdominal cramps
Back pain
Dysphoria
0edema
vaginal bleeding,
Breast tenderness
Storage conditions
keep on room temperature
Cool dry place
Route of administration
Intramuscular injection
Orally
Contraindications
During the first 4 months of pregnancy
Excreted in breast milk
Side effects
Weight gain and oedema
Decreased glucose tolerance
Disturbed liver function
Visual disorders
Menstrual changes
Oestrogens
Mechanism of action
Regulation of mammalian reproduction
These hormones act by regulating the transcription of specific genes in the uterus
The actions of these hormones are mediated by their specific hormone receptors
Indications
Osteoporosis
Amenorrhea
Atrophic vaginitis
Dysfunctional bleeding
Postmenopausal
Contraindications
During pregnancy
May suppress lactation and should not be given during breast feeding
Side effects
Breast tenderness and discharge
Fluid retention, body weight changes
Reduced glucose tolerance
Headache
Leg cramps, back pain
Storage conditions
Keep it in dry cool place
Room temperature
Route of administration
Orally
Intramuscular
Progestin
Mechanism of action
Inhibition of follicular development, ovulation, and as consequence, corpus luteum formation
it is also involved in the alteration of the cervical mucus that inhibit sperm penetration.
Indications
Amenorrhea
Endometrial hyperplasia associated with conjugated estrogen replacement therapy
For the treatment of dysfunctional uterine bleeding secondary to hormonal imbalance
Contraindications
Endometrial cancer
Patients with undiagnosed vaginal bleeding
Patients with pre-existing breast cancer
Side effects
Spotting or irregular vaginal bleeding
Loss of libido
Prolonged periods
Abdominal bloating
Dizziness
Headache
Storage condition
Room temperature
Cool dry place
Route of administration
Intramuscular
Orally