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antiathritic drugs (APREMILAST (ROUTE OF ADMINISTRATION (orally.), SIDE…
antiathritic drugs
APREMILAST
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SIDE EFFECTS
diarrhea, severe gastrointestinal symptoms.
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MECHANISM OF ACTION
is an inhibitor of PDE4 . in vivo models of arthritis , was specifically identified as a downstream target of apremilast.
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ASPIRIN
DEFINITION
is a non-steroidal anti-inflammatory drug that is used to reduce pain associated with arthritis ,including pain and swelling in the joints.
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MECHANISM OF ACTION
causes reduction of inflammation, anagelsia, prevention of clotting , and the reduction of fever
INDICATIONS
is used for rheumatic diseases including chronic polyarthritis, osteoarthritis.
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SIDE EFFECTS
heart burn, upset stomach , severe nausea, persistent migraines, extreme fatigue
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STORAGE CONDITIONS
keep in a cool , dry place away from heat and moisture
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AZATHIOPRINE
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MECHANISM OF ACTION
inhibits purine synthesis. by inhibiting purine synthesis ,less DNA and RNA are produced for synthesis for white blood cells,causing immunosuppression
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CONTRAINDICATIONS
pregnancy, severe infection , severe anemia, decreased blood platelet, acute inflammation of the pancrease.
SIDE EFFECTS
nausea , vomiting , dizziness , diarrhoea , fatigue and skin rashes.
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ABATACEPT
DEFINITION
is a drug used to autoimmune diseases like rheumatoid arthritis , by interfering with the immune activity of T-cells , it is a modified antibody
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MECHANISM OF ACTION
prevents antigen-presenting cells from delivering the co-stimulating signal.this prevents the T-cells from being fully activated ,and even down regulates them
INDICATIONS
reduces signs and symptoms of major clinical response.inhibiting the progression of structural damage , and improving physical function.
CONTRAINDICATIONS
causes birth defect in rodents when given in very high doses, transmitted in rodent breast milk. it should not be used in combination with anakinra or TNF antagonist.
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SIDE EFFECTS
infections, anaphylactic reactions to the drug, slow growing cancers, pneumonia , stomach pain, diarrhea, nasea ,vomitting
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ALLOPURINOL
DEFINITION
used to prevent gout, types of kidney stones and for high uric acid levels that can occur with chemotherapy.
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INDICATIONS
is used in gouty arthritis, skin tophi , kidney stones , idiophathic gout , uric acid lithiasis , acute uric acid nephropathy.
SIDE EFFECTS
skin rash, fever, eosinophilia, hepatitis and worsened renal function.
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