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ANTIMYASTHENIC DRUGS (INDICATIONS (Edrophonium diagnoses myasthenic gravis…
ANTIMYASTHENIC DRUGS
INDICATIONS
- Edrophonium diagnoses myasthenic gravis
- Edrophonium also distinguishes cholinergic crisis from myasthenic crisis
- Neostigmine and pyridostigmine control myasthenic gravis symptoms
- Test acetylcholine receptor antibodies
- Used to treat or diagnose myasthenic gravis
- Neostigmine/pyridostigmine may be given by injection as an antidote to certain types of muscle relaxants used in surgery
NURSING CONSIDERATIONS
SIDE EFFECTS
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- Increased salivation and increased bronchial secretions
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CONTRA- INDICATIONS
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- Edrophonium is contraindicated in bromide allergy
STORAGE CONDITIONS
- Keep out of the reach of children.
- Store in a closed container at room temperature, away from heat, moisture, and direct light.
- Do not keep outdated medicine or medicine no longer needed.
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EXAMPLES
- Ambenonium chloride (Myetelase)
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- Pyridostigmine (Mestinon)
MECHANISM OF ACTION
- Relieve muscle weakness associated with myasthenia gravis
- By blocking acetylcholine breakdown at the neuromuscular junction