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Antigout drugs (Colchine (Mechanism of action (Bind to tubulins., Inhibit…
Antigout drugs
Colchine
Mechanism of action
Bind to tubulins.
Inhibit inflammatory cells in gouty tissue.
Inhibit migration of cancer cell.
Inhibit phagocytosis of uric acid.
Indications
Treat gout attacks.
Prevent pericarditis.
Prevent attack of pain in abdomen.
Nursing consideration
Side effect
Muscle pain.
Vomitting.
Diarrhea.
Fever.
Body aches.
Contraindications
Dialysis.
Renal disease.
Renal failure.
Renal impairment.
Route of administration
Orally.
Injectable.
Strorage condition
At room temperature.
Away from reach of children.
Away from light.
Protect from light.
Allopurinol
Mechanism of action
Inhibit purine synthesis.
Inhibit enzyme xanthine oxidase.
Block uric acid production.
Indications
Decrease high blood uric acid level.
Prevent gout.
Different types of kidney stones.
Nursing consideration
Side effect
Headache.
Drowsiness.
Diarrhea.
Muscle pain.
Vomiting.
Route of administration
Orally.
Contraindications
Chronic heart failure.
Liver problem.
Allergic reaction.
Extreme loss of body water.
Storage
Away from heat.
Away from sunlight.
Keep out of reach of childrens.
Sulfinpyrazone
Mechanism of action
Block simultaneously administration of citrates.
Inhibit reabsorption of uric acid.
Facilitate urinary excretion of uric acid.
Inhibit multidrug resistance protein.
Indictions
Treat gout.
Reduce platelet aggregation.
Reduce the release of ADP.
Nursing consideration
Side effect
Heart burn.
Rash.
Nausea.
Abdominal pain.
Vomiting.
Contraindications
Renal impairment.
Kidney stones.
Peptic ulcer.
Pregnant women.
Storage condition
Room temperature (15-30 degrees Celsius).
Away from light.
Away from moisture.
Away from children.
Route of administration
Orally.
Probenecid
Mechanism of action
Inhibit renal tubular transporter.
Facilitate excretion of uric acid caused by disease.
Block reuptake.
Inhibit renal excretion.
Indications
Treat gout.
Increase uric acid excretion.
Treat hyperuricemia.
Nursing consideration
Side effect
Nausea.
Stomach pain.
Cramping.
Loss of appetite.
Dizziness.
Frequent urination.
Contraindication
Kidney diseases.
Stomach ulcer.
Anemia.
Renal impairment.
Storage
Away from light.
At room temperature (68-77 degrees F).
Route of administration
Oral.