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ANTIGOUT DRUGS ((CONTRAINDICATIONS (Extreme loss of body water, Chronic…
ANTIGOUT DRUGS
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MECHANISM OF ACTION
Allopurinol and its active metabolites, oxypurinol, inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid. Elevated concentrations of oxypurine and oxypurine inhibition of xanthine oxidase through negative feedback results in a decrease in the concentration of uric acid in the serum and urine
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MECHANISM OF ACTION
Febuxostat is a non-punne-selective inhibitor of xanthine oxidase. It works by non- competitively blocking the molybdenum pterin center which is the active site on xanthine oxidase..
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Febuxostat inhibits both oxidized as well as reduced form of xanthine oxidase because of which febuxostat cannot be easily displaced from the molybdenum pterin site
CONTRAINDICATION
Because of possible increases in the plasma concentrations with febuxostat this agent is contraindicated in patients using azathioprine, mecaptopurine or theophylline. As with other medication, febuxostat should not be administered to patient with hypersensitivity to any component of the product.
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INDICATION
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Increased amount of uric acid can cause gout therefore febuxostat help to reduce amount of uric acid
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NAME
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MECHANISM OF ACTION
Prednisone is a commonly used catabolic steroid that binds to cytoplasmic receptors and inhibits DNA synthsis
Prednisone is converted to the active form, prednisolone, in the liver.
Anti-inflammatory effects are complex, but via binding to cellular glucocorticoid receptor, prednisone act to inhibits inflammatory cells and suppress expression of inflammatory mediators.
INDICATIONS
Use to treat conditions such as Gout, blood disorders, breathing problems, skin diseases, severe allergies and immune system disorders
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