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Anti arthritic drugs (Methotrexate (mechanism of action (the inhibition of…
Anti arthritic drugs
Methotrexate
Defination
, is a chemotherapy agent and immune system suppressant
mechanism of action
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Iinhibition of T cell activation and suppression of intercellular adhesion molecule expression by T cells;
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inhibition of methyltransferase activity,
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Another mechanism of MTX is the inhibition of the binding of interleukin 1-beta to its cell surface receptor.
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Indication
is used to treat certain types of cancer of the breast, skin, head and neck, or lung.
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Celebrex
Indication
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Also use ankylosing spondylitis, and menstrual pain.
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Side effect
stuffy nose, sneezing, sore throa
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Mechanism of action
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Both COX-1 and COX-2 are involved in converting arachidonic acid to prostaglandin H2,
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The accumulation of prostaglandins, particularly prostaglandin E2,
, causes inflammation, pain and swelling as part of the healing process
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Plaquenil
Indication
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treat or prevent malaria,
Mechanism of action
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and leads to the production of interferon and causes the dendritic cells to mature and present antigen to T cells
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Side effect
nausea, vomiting, stomach pain;
loss of appetite, weight loss;
mood changes, feeling nervous or irritable;
headache, dizziness, ringing in your ears
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Meloxicam
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Storage
Store at room temperature,
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Mechanism of action
Meloxicam blocks cyclooxygenase (COX), the enzyme
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he first step in the synthesis of prostaglandins, which are mediators of inflammation
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Contraindication
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a history of heart attack, stroke, or blood clot;
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