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Antiparkinsonian drugs (Amantadine (Contraindications (Heart failure,…
Antiparkinsonian drugs
Amantadine
Mechanism of action
It interferes with the release of infectious viral nucleic acid into the host cell through interaction with the transmembrane domain of the M2 protein of the virus.
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Contraindications
Heart failure, orthostatic hypotension, peripheral edema, syncope.
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Dialysis, renal failure, renal impairment.
Depression, psychosis, schizophrenia, substance abuse, suicidal ideation.
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Apomorphine
Mechanism of action
R-enantiomer is an agonist of both D1 and D2 dopamine receptors, with higher activity at D2.
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Indications
Acute, intermittent treatment of hypo-mobility, off episodes.
Indicated for the acute, intermittent treatment of hypomobility, off episodes.
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