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selective estroge -receptor modulators (contraindications (risk of venous…
selective estroge -receptor modulators
name
raloxifene
machanism of action
it reduces the serum total and low-density lipo-protein cholesterol concentration.raloxifene bind to oestrogen receptors resulting in defferent expression of multiple oestrogen regulated genes in different tissues.
contraindications
risk of venous thromboembolism
in postmenopausal woman has high risk for breast cancer
should not give patient with stroke
should not give to patient with coronary diseases
side effect
leg cramps
hot flashes
indications
prevent osteoporisis
reduces the risk of hip fracture
increases the bone denstity without the risk of endomentrial cancer
reduce the risk of invasive breast cancer in postmenopausal woman with osteoporiss
routes of administration
administered orally.
storage condition
store at controlled temperature 20 to 25 degree celcius