Antilipemic drugs.
Bile- sequestering drugs.
Mechanism of action.
Indications.
Nursing considerations.
Contra- indications.
Side effects.
Storage conditions.
Route of administrations.
Treats hypercholesterolemia.
Pruritus.
Itching.
Oral.
Room temperature.
Away from light.
Away from moisture.
Diet.
Exercise.
Improve glycemic control.
Binds bile acids in the intestine.
Bloating.
Constipation.
Skin fflushing.
Headache.
Vomiting.
Myalgia.
Bile acid pool becomes depleted.
Hepatic enzyme is upregulated.
It increases the convesion of cholesterol to bile acids.
Causes an increase demand for cholesterol to bile acids.
Fibric acid derivitaves.
Mechanism of action.
Affect triglyceride and cholesterol rich particles.
Indications.
Nursing consideration.
Contra-indications.
Side effect.
Storage condition.
Route of administration.
Reduce high triglycerine levels.
Decrease risk of cardiovascular disease.
Reduce production of progressive retinopathy.
Reduce cholesterol levels.
Hyperlipidemia.
Hypertryglyceridemia.
Patients with severe renal impairment.
Patients with liver disease.
Gallbladder disease.
Nursing mothers.
Pregnant women.
Obese patients.
Limitation of substrate availability for triglyceride synthesis in the liver.
Promote the action lipoprotein lipase.
Modulation of low density lipoprotein receptor.
Stimulation of reverse cholesterol.
Nausea.
Stomach upset.
Diarrhea.
Room temperature.
Away from moisture.
Away from light.
Keep in cool dry place.
Out of reach of children.
Orally.
HMG- COA Reductase.
Mechanism of action.
Indications.
Nursing consideration.
Contra- indications.
Side effect
Storage conditions.
Route of administration.
Muscle pain.
Liver damage.
Neurological side effects.
Room temperature.
Away from moisture.
Away from light.
Orally.
Breast feeding.
Pregnancy.
Hypothyroidism.
Jaundice.
Hepatic disease.
Catalyzes the commited stop in cholesterol biosynthesis.
Statins are HMGR inhibitors.
Effectively lower serum cholesterol levels.
Removes bile acids from the body.
Forming insoluble complexes with bile acids in the intestine.
Then excreted in the faeces.
Treat hypercholesterolemia.
Treat the pruritus.
Treat itching.
Eliminate blood acids.
Treat diarrhea.
Plasma cholesterol is convected to bile in the liver to normalize levels.
Examples.
Simvastatin.
Atorvastatin.
Cholesyramine.
Nicotic acid.
Dysproteinemia.
Hyperthyroidism.
Kidney disease.
Alcoholism.
Diabetes.