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Antilipemic drugs. (Examples. (Simvastatin., Atorvastatin., Cholesyramine.…
Antilipemic drugs.
Examples.
Simvastatin.
Atorvastatin.
Cholesyramine.
Nicotic acid.
Bile- sequestering drugs.
Mechanism of action.
Binds bile acids in the intestine.
Bile acid pool becomes depleted.
Hepatic enzyme is upregulated.
It increases the convesion of cholesterol to bile acids.
Causes an increase demand for cholesterol to bile acids.
Indications.
Treats hypercholesterolemia.
Pruritus.
Itching.
Diet.
Exercise.
Improve glycemic control.
Nursing considerations.
Contra- indications.
Dysproteinemia.
Hyperthyroidism.
Kidney disease.
Alcoholism.
Diabetes.
Side effects.
Bloating.
Constipation.
Skin fflushing.
Headache.
Vomiting.
Myalgia.
Storage conditions.
Room temperature.
Away from light.
Away from moisture.
Route of administrations.
Oral.
Fibric acid derivitaves.
Mechanism of action.
Affect triglyceride and cholesterol rich particles.
Limitation of substrate availability for triglyceride synthesis in the liver.
Promote the action lipoprotein lipase.
Modulation of low density lipoprotein receptor.
Stimulation of reverse cholesterol.
Indications.
Reduce high triglycerine levels.
Decrease risk of cardiovascular disease.
Reduce production of progressive retinopathy.
Reduce cholesterol levels.
Hyperlipidemia.
Hypertryglyceridemia.
Nursing consideration.
Contra-indications.
Patients with severe renal impairment.
Patients with liver disease.
Gallbladder disease.
Nursing mothers.
Pregnant women.
Obese patients.
Side effect.
Nausea.
Stomach upset.
Diarrhea.
Storage condition.
Room temperature.
Away from moisture.
Away from light.
Keep in cool dry place.
Out of reach of children.
Route of administration.
Orally.
HMG- COA Reductase.
Mechanism of action.
Catalyzes the commited stop in cholesterol biosynthesis.
Statins are HMGR inhibitors.
Effectively lower serum cholesterol levels.
Removes bile acids from the body.
Forming insoluble complexes with bile acids in the intestine.
Then excreted in the faeces.
Plasma cholesterol is convected to bile in the liver to normalize levels.
Indications.
Treat hypercholesterolemia.
Treat the pruritus.
Treat itching.
Eliminate blood acids.
Treat diarrhea.
Nursing consideration.
Contra- indications.
Breast feeding.
Pregnancy.
Hypothyroidism.
Jaundice.
Hepatic disease.
Side effect
Muscle pain.
Liver damage.
Neurological side effects.
Storage conditions.
Room temperature.
Away from moisture.
Away from light.
Route of administration.
Orally.