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antigout (Allopurinol. (indications (used to prevent gout, prevent…

- - - - extreme loss of body water.
      - chronic heart failure.
      - Allergic Reaction causing Inflammation of Blood Vessels.
      - liver problems.
      - moderate to severe kidney impairment.
  - - - flu symptoms, joint pain, easy bruising, unusual bleeding
      - painful urination, blood in the urine
      - numbness, tingling, burning pain
      - worsening gout symptoms
- - - - inhibits microtubule polymerization by binding to its constitutive protein, tubulin.
      - as availability of tubulin is essential to mitosis, colchicine may inhibit mitosis.
      - inhibits activation and migration of neutrophils to sites of inflammation.
      - interferes with the inflammasome complex found in neutrophils and monocytes that mediate interleukin-1β activation, a component of inflammation.
      - inhibits superoxide anion production in response to urate crystals.
      - interrupts mast cell degranulation.
  - - - low level of granulocytes in the blood
      - muscle problems
      - method of removing waste/poison from blood with dialysis
      - severe liver disease
      - severe renal impairment
      - rhabdomyolysis