Bisphosphanates (Alendronate) (Mechanism of action (bisphosphates…
indivividual with severe ranal impairment
store in a well closed container at room air 15-30 degree celcius
Mechanism of action
bisphosphates decrease osteoclastic bone reabsorbtion via several mechanisms.
inhibitation of cholesterol biosynthetic pathway.
increase in osteoclastic apostosis
inhibitation of the osteoclastic proton pump for dissolution of hydroyapatite
decrease risk of bone fracture
treating postmenopausal osteoporisis
prevention of postmenopausal osteoporis
increase bone mass
Route of administration
orallly active agents for osteoporosis can be dosed daily or once weekly orally.
administered with 6 to 8 ounces of plain water at least 30 minutes before eating breakfast