Please enable JavaScript.

Coggle requires JavaScript to display documents.

Bioactive Glasses (Applications (Bonalive (Paste (Suspension of bioglass…

- - - - Suspension of bioglass in glycerol
      - Particles cut gloves
      - Covers up some bioactivity
- - - - Reduced network dissolution
  - - - B2O3
      - P2O5
      - SiO2
    - - ~Q2 gives good bioactivity
      - High n makes it hard to break down
- - - - HCA formation
      - Dissolution products stimulate cells
        
        Matrix production
        
        Attachment of molecules
        
        Growth factors
        
        Enzymes
        
        Inflammatory mediators
        
        Stimulate gene expression (esp. osteoblasts)
        
        Too much silica becomes toxic
  - - - Insufficient Tg -Tc window
      - Reduces bioactivity
    - - Coating peels off
- - - - Breaking of Si-O-Si bonds
        & continued formation of Si-OH
        bonds at interface
        
        3.Condensation & repolymerisation
        of SiO2-rich layer on surface
        
        Depleted in alkalis and alkali-earth cations
        
        Migration of calcuim and
        phosphate groups to surface
        
        CaOP2O5 layer on top of SiO2 layer
        
        Crystallisation of amorphous
        film -> mixed HCA layer
        
        Incorporation of OH and
        CO3 anions from alution
  - - - Activates differentiation of stem cells
      - Action of macrophages
        to remove debris
        
        Cells occupy resulting space
        
        Attachment of stem cells
        
        Differentiation
        of stem cells
        
        e.g. Osteoblasts
        
        Generation of ECM
        
        Crystallisation
        of inorganic matrix
        
        Encloses bone cells
        in living composite
        
        Osteoblasts -> osteocytes