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Blood products (Consent (Type of blood/product, Indication, Benefits,…
Blood products
Consent
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Risks (incorrect type, acute reaction,
haemolysis, infection, circulatory overload)
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Red cells
Complications
Acute transfusion reactions
Non-haemolytic febrile reaction
Haemolytic (ABO, non-ABO)
Allergic
Anaphylactic
Infections
Bacteria, viruses, parasites, prions
Very rare
Prescription
I unit increases Hgb 10g/L for 70kg adult
Nomenclature red cells, over specific time frame
Requirements e.g. irradiated, HepE/CMV negative
250ml over 2-4h, dont give >4u without platelets/FFP
Indications
Major haemorhage (acute loss, haemodynamically unstable)
Acute anaemia <70g/L (<80g/L if comorbidity)
Chronic anaemia (transfusion dependent)
Exchange transfusion (e.g. haemaglobinopathy)
Platelets
Indications
BM failure
Active bleeding or prophylaxis
Conditions: DIC, ITP, platelet dysfunction
Contraindications
TTP, HIT
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Cryoprecipitate
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Pathophysiology
From whole blood from male donors
Concentrated plasma: rich in FVIII and fibrinogen
Contains clotting factors, Ig, fibronogen, etc
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FFP
Pathophysiology
Whole blood from male donors (no Rh sensitisation)
Must be ABO matched (contains Abs, clotting factors, etc)
Increases clotting
Indications
Major haemorrhage
Replacement of coagulation factors (DIC, liver disease, Factor V Leiden)
Plasma exchange
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