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Protein Adsorption (Measuring (See Wei et all 2014 for more (Microbalance,…

- - - - Each site can only be occupied by a single protein
      - Proteins can reversibly attach
- - - - Water rearranges to maintain H bonds
      - Hydrophobic surfaces cannot form H bonds
      - Penalty ∝ A of hydrophobic patch
      - Constant = solid-liquid interface free energy of water
    - - Situation
        
        Charged surface
        
        Protein
        
        Charge distribution
        
        small mobile ions
        
        Salt buffer
      - Assumptions
        
        Salt ions
        
        Mobile
        
        Thermal equilibrium
        
        Electrostatic energy interaction
      - Solution derived from Poisson-Boltzmann
        and Debye-Huckel approximation
        
        Different orientations have different energies
        
        Can be repulsive
    - - Many free states but limited adsorbed states
      - Results in a loss of entropy