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Comorbidity (Pennington (2006) (Hyp (RD only: phonological deficits only,…
Comorbidity
Pennington (2006)
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Hyp
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If they are two independent dis, should see different cog + genetic risk profiles
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Twin study logic
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If disorders/traits are genetically correlated, molecular genetic analyses should focus on finding common genes
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Multiple deficit model
Levels
- Cog level
- Interactive deve
- Pheiotropy = single cause associated with range of different outcomes
- Neural level
- Diagnostic (behavioural) level
- Comorbidity
- GxE interaction - enviro factors which impact on expression of genetic types > phenotypes
- GxE correlation - genetic predispositions co-occur w/abnormal enviro candidates
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Factors alter neural + cog processing, + subsequent behaviour
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Risk factors = shared between different disorders (comorbidity = expected), but way risks combine/exert effects is unpredictable
Comorbidity
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Co-occurrence of two or more disorders, at greater rates than would be predicted by chance
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