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CR - Arteritis (intro (main disease processes of arts (inflamm…

- - - - RA
      - SLE
      - Henoch schonlein purpura (HSP - mainly in children)
    - - ANCA - Granulomatosis with Polyangitis (GPA, formerly known as Wegener's granulomatosis) (Dx with blood test)
      - anti-GBM Igs - Goodpastures (small vessel - young adult men - haematuria + haemoptysis)
- - - - granulomatous
      - affects aorta + major branches + extracranial branches of carotid
      - over 50s
      - emergency - blindness risk - give high dose steroids straight away
    - - granulomatous
      - affects aorta + major branches
      - marked intimal thickening - min residual lumen
      - under 50s
      - hard to Dx - do aortic arch angiogram
      - destruction of media by mononuclear inflamm + giant cells
  - - - affects renal + systemic vessels
      - spares pul circulation
      - no vasculitis in arterioles, capills or venules
    - - lumen occluded by thrombus (may contain abscesses) + inflamm
      - vessel wall infiltrated with lymphocytes
      - ischaemia of tissue supplied by affected art
  - - - necrotising vasculitis + granulomatous inflamm of resp tract
        
        large nodular lung lesions
      - necrotising glomerulonephritis
    - - necrotising vasculitis
      - esp in asthmatics
      - granulomatous inflamm of resp tract
      - blood eosinophilia
    - - systemic ICD
      - rash on legs + buttock
      - sometimes kidney involvement
      - joint pain (sore knees)