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CR - Heart failure (i) (Aetiology (storage disorders (glycogen storage,…
CR - Heart failure (i)
intro
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symptoms severity varies during natural hx = may not always correlate with changes in underlying cardiac function
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66% = reduced EF (ischaemia, dilated)
preserved EJ: non-dilated, dias (filling) dysfunction
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continuum
- Risk factors (hypertension, dyslipidaemia, high BMI, smoking, family Hx)
- atherosclerosis -> CAD -> LVH
- Coronary thrombosis -> MI -> arrhythmia -> dilatation + remodelling -> HF
- hospitalisations -> end stage heart disease -> reduced QOL -> death
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Neurohormonal model
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morbidity + mortality due to pump failure, arrhythmias
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