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Altered Hormone & Metabolic Function (Syndrome of Inappropriate…
Altered Hormone & Metabolic Function
Syndrome of Inappropriate Antidiuretic Hormone Secretion
Cause:
Tumor
Manifestation
Decreased Urine Output
Anorexia
Vomiting
Disorientation
Muscle Cramps
Diagnostic Criteria
Decreased Urine Output
Blood Testing
Serum Sodium < 135 mEq/L
Plasma Osmolality < 280 mOsm/kg
Treatment
Fluid Restriction
Medications
Surgical Removal of Tumor
Diabetes Insipidus
Insufficient ADH
Causes
Poor Production of ADH by Hypothalmus
Altered Kidney Response to ADH
Excessive Fluid Intake
Manifestation
#
Polyuria
Dilute Urine
Excessive Thirst
Severe Dehydration
Diagnostic Criteria
History/Physical
Blood/Urine Test
Treatment
Fluid Intake
Pharmacologic
Desmopressin
Hyperthyroidism
Excess Thyroid Hormone
Graves Disease
Manifestations
Weight Loss
Restlessness
Heat Intolerance
Tachycardia
Tremors
Diagnostic Criteria
#
Family/Personal History
Physical Exam
Elevated Serum TSH
Treatment
Radioactive Iodine
Medications
Surgical Removal of Thyroid
Hypothyroidism
Decreased Thyroid Hormone
Congenital
Acquired
Treatment
Pharmacologic
Levothyroxine
Diagnostic Criteria
Lab Values
Decreased Thyroid Hormone
Increased TSH
Sensitive TSH Assay
Physical/History
Manifestations
Fatigue
Cold intolerance
Weakness
Weight Gain
Impaired Reproduction
Cushing Syndrome
Prolonged Exposure to:
Endogenous Glucocorticoids
Exogenous Glucocorticoids
Manifestation
Obesity
#
Moon Face
Buffalo Hump
Muscle Wasting
Osteoporosis
Diabetes
Hirsutism
Treatment
Surgical/Radiation Removal of Tumor
#
Pharmacologic
Corticosteroid
Diagnostic Criteria
Urine Screen
Imaging
Addison Disease
Destruction of Adrenal Cortex
Inability to produce:
Glucocorticoids
Mineralocorticoids
Androgens
Manifestatons
Decreased Hormone Levels
#
Darkening of Skin
Treatment
Isotonic Infusion
Antibiotics (tuberculosis dx)
Pharmacologic
Glucocorticoud
Mineralocorticoid