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News n Views (The study (Grafts, imaging trajectories. iAFM stiffness of…
News n Views
The study
Grafts, imaging trajectories. iAFM stiffness of mesoderm
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Various methods of changing stiffness of mesoderm (ablation, AFM stress, myosin morpholinos/constiuatively active myosin) to test migration
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Measured cell densities under neural crest, with stiffening and migration
after convergent extension, the main factor for stiffness is cell density
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Intro
Summary
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CCM
essential for morphogenesis, cancer
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Link between gastrulation and NC migration, tissue mechanics + molecular effectors coordinate morphogenesis
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Wider context, future
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Links to cancer
Furthers tissue microenvironment role, consideration in in vitro
Study into these effects, blocking PCP effects on metastasis
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