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CR - Asthma (i) (Intro (neural hyperresponsiveness (irritation) - cough…

- - - - diurnal variation
        
        adrenaline (bronchodilator) lowest @ 4am
        
        cortisol (anti-inflamm) lowest @ 12am
      - no diurnal variation in COPD
- - - - mass that changes liquid to mist
      - can often be used for people who find it hard to use inhaler (young children)
- - - - salmeterol
      - formeterol
    - - symptom relief
      - salbutamol
      - terbutaline
  - - - Cushing's (obesity, striae, myopathy, glaucoma, osteoporosis, DM, bruising, peptic ulcer disease-PUD)
- - - - NA + adrenaline
      - beta Rs
      - indirectly inhibit smooth muscle contraction by inhibiting parasymps
    - - ACh
      - muscarinic/cholinergic Rs
      - mucus + contraction