Please enable JavaScript.

Coggle requires JavaScript to display documents.

Immune system (Introduction and Overview (Innate Immunity (Complement (If…

- - - - Proteins in plasma and lymph, once triggered, several activation events
      - Forms Membrane Attack Complex (MAC)
      - Major role: Opsonization
      - If doesnt work
        
        Severe invasive infections with encapsulated (Carb-coated) bacteria
        
        e.g. S. Pneumoniae, H. Influenzae and Neisseria meningitidis
    - - First deployed
      - Digest what they eat and present to T cells through Major Histocompatibility Complex (MHC)
      - If does work
        
        Soft tissue abscesses or lymphadenitis
        
        Catalase (+) organisms (Staph arueus, serratia marcesans, Aspergillus)
        
        Poor wound healing
  - - - Make and deploy antibodies (can deploy at or near site, or distant)
      - If doesnt work
        
        Recurrent bacterial sinopulmonary infections
        
        Sinusitis, Ear infections, Bronchitis, Pneumonias with bacteria such as S. Pneumoniae, H. Influenza, Moraxella Cattarhalis
    - - CD4: Helper T cells
      - CD8: Cytotoxic T cells that kill cells infected with intracellular pathogens like virus or fungi
      - Regulatory T cells control and modulate immune response (prevent autoimmunity)
      - If dont work
        
        Inability to generate effective AB response
        
        Severe Viral infections
        
        Severe Fungal INfections (Pneumocystis Jirovecii)
        
        Autoimmunity