Please enable JavaScript.

Coggle requires JavaScript to display documents.

Lectin Pathway (Mannose binding lectin (Ficolins (Activate pathway…

- - - - Binding MBL to mannose residues on pathogen activates MASP-1 and MASP-2
        
        ficolins are homolous to MBL and function via MASP but to other carbohydrates not just lactose
        
        Identical to Classical pathway; C2 is cleaved into C2a and b; C4 to C4a and b By the MBL/ MASP complex or Ficcolin/ MASP complex. It forms C4b2b complex
        
        functionally C4b and C2b form the C3 convertase, later joining with C3b to make C5 convertase
        
        Complex C4b2b binds with C3b to form C4b2bC3b
        
        C5 will be cleaved by C5 convertase to form C5a and C5b
        
        1 more item...
      - Opsonization via MBL or Ficolins
        
        Causes signal amplification through a feedback loop
- - - - This conformed C5b will attach to C6, C7, C8, and multiple C9 monomers to form the Membrane attack complex ( MAC).
        
        Lysis of pathogenic cells
- - - - activated C1 cleaves C4
        
        resulting in reactive C4b
        
        C4b covalently binds near C2
        
        bound C4b binds to C2, allowing C2 to be active for proteolysis by C1
        
        forms C4b2a complex
        
        C3 convertase cleaves C3 to C3a and C3b
        
        3 more items...