Please enable JavaScript.
Coggle requires JavaScript to display documents.
von Willebrand disease (Clinical
presentation (Epistaxis, Bleeding,…
von Willebrand disease
-
Diagnosis
Examination
General
Bruising, bleeding
Investigations
Bloods
FBC (nil, unless large blood loss)
Clotting (PT normal, APPT prolonged)
U+E, LFT, TFTs
-
History
-
-
PC/HPC
Bleeding, bruising,
prolonged epistaxis, menorrhagia
-
SH
Living arrangements, school/nursery/occupation
Management
Conservative
Information, advice, support
MDT (haematologist, specialist nurse)
Lifestyle (avoid contact sports, avoid certain meds
i.e. NSAIDs, aspirin, IM injections)
-
-
-
Pathophysiology
Normal role vWF
Promote platelet adhesion to damaged endothelium
Promote platelet-platelet adhesion
Carrier protein for FVIII
-
Defect
AD, AR or other inheritance
May types of mutation (varied severity of disease)