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Retinoblastoma (Management (Medical (Chemotherapy
Indication: bilateral…
Retinoblastoma
Management
Medical
Chemotherapy
Indication: bilateral tumours
E.g. carboplatin, atopside, vincristine
Radiotherapy
Indication: advanced disease
MOA: external beam, brachytherapy
SE: may cause cancers in radiation field
Cryotherapy, transpupillary thermotherapy
Indication: small tumours
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Conservative
Information, advice, support
MDT (ophthalmology, paeds, specialist nurse,
psychologist, counselling)
Genetic screening (parents, siblings)
Complications
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Other primary tumours
e.g. pineal, sarcomas, etc.
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Diagnosis
Examination
Fundoscopy
Leukocoria (white pupil),
Strabismus
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History
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PC/HPC
White pupil, squint
POH
Scans, bloods (ID?), growth, gestation,
delivery, weight, complications
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SH
Living arrangements, school/nursery
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Pathophysiology
Defect
AD inheritance of mutation in Rb tumour suppressor,
making Rb non-functional
Subsequent somatic mutation in Rb causes disease
Bilateral is always inherited, 20% unilateral inherited
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Prognosis
Often curable, but visual
impairment in most
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