Fibrocystic disease:
Most common lesion of breast. Causes a spectrum of changes, including dilatation of ducts (cyst formation), apocrine metaplasia, stromal fibrosis, inflammation and duct hyperplasia. Oestrogen predominance over progesterone is considered as a cause.
Clinical picture:
There is localized, generalized, or bilateral lumpiness (ill-defined lesions) of the breast. The mass may be painful and tender. It occurs mostly in women 30-50 year age. Needle tip may be deflected by fibrotic areas of the lesion. Sometimes only fluid may be aspirated
Fibrocystic Cytologically, the sample consists of Low-moderate cellularity, with cohesive sheets of ductal cells in honeycomb pattern. Naked, bipolar myoepithelial cells in background or attached to sheets of ductal cells. Fat and stroma are seen in variable amounts. Variable numbers of apocrine cells (apocrine metaplasia) and foam cells present. High cellularity or mild epithelial atypia may be seen in ductal hyperplasia