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Neuroblastoma (Clinical
presentation (Abdominal mass, Weight loss, Bony…
Neuroblastoma
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Diagnosis
Examination
Abdo exam
Pallor, abdominal mass,
hepatomegaly
Investigations
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Bedside
Obs (nil)
Height, weight (weight loss)
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History
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PC/HPC
Abdominal mass, weight loss,
anorexia
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SH
Living arrangements, school/nursery
Management
Medical
Chemotherapy
Indication: metastatic disease, neoadjuvant/adjuvant
MOA: destroys cancer cells, can be curative
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Surgery
Tumour removal
Indication: localised disease
MOA: bulk removal of tumour,
can be curative
Conservative
Information, advice, support
MDT (medic, surgeon, specialist nurse,
psychologist, counselling)
Pathophysiology
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Mechanism
Forms tumour along site from neck to pelvis (along SNS chain)
Can spontaneously regress
Can be benign (ganglioneuroma) or malignant (neuroblastoma)
May metastasise to bone, causing pain, limp, pathological fracture
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