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Brain tumours (Clinical
presentation (Vomiting, Behavioural change,…
Brain tumours
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Pathophysiology
Ependymoma
Posterior fossa, spinal cord
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Craniopharygoma
Developmental, arises from
remenant of Rathke pouch
Astrocytoma
Commonest type of primary brain tumour
Supratentorial, cortex
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Meningioma
Common, benign
Arise from the meninges
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Diagnosis
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Investigations
Bloods
FBC, U+E, LFTs, clotting, TFTs, B12, folate (all normal)
LP
CSF for MCS, cytology (may show malignant cells)
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Imaging
CT head: visible mass,
type often estimatable by location
and morphology
Whole body CT: identify primary/mets
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History
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PC/HPC
Headache, vomiting, behaviour change,
seizures,balance and coordination,
visual changes
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SH
Living arrangements, occupation/school,
smoking alcohol
Management
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Conservative
Information, advice, support
MDT (medic, surgeon, specialist nurse,
psychologist, counselling)
Epidemiology
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Primaries uncommon in adults,
much more likely to be secondary
Prognosis
Good for meningioma, poor for gliomas,
medulloblastoma, astrocytomas
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