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Kleinfelter's
syndrome (Clinical
presention (Gynaecomastia
…
Kleinfelter's
syndrome
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Diagnosis
Examination
General: tall stature, gynaecomastia
Genital: small testes
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History
Gynaecomastia in adolescence,
fertility problems, often normal puberty
Management
Conservative
Information, advice, support
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Prognosis
Good, usually have
normal intellingence
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Pathophysiology
Defect
Non-disjunction of sex chromosomes,
XX or XY in one gamete, when fertilised becomes XXY