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Morphine (PK Properties (Absorption: absorbed from GI tract, but…
Morphine
PK Properties
Absorption: absorbed from GI tract, but significant 1st pass metabolism (bioavailability 25%), typically given parentally or intrathecal or via epidural
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PD Properties
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Respiratory depression (caused by decreased responsiveness to CO2+ other effects) rare in clinical dosing (caution with those with respiratory problems)
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